Myocardial Balance of Inorganic Phosphate and Enzymes in Man Effects of Tachyeardia and Ischemia

Myocardial balance of inorganic phosphate and enzymes in man. Effects of tachycardia and ischemia.

The effects of atrial pacing on the cardiac balance of inorganic phosphate (Pi) were studied during control, atrial pacing, and recovery periods in 29 patients. Group A (n= 18) who had roentgenographically demonstrated coronary artery disease (CAD) developed angina during pacing, and showed mean myocardial lactate (L) production, abnormal left ventricular end-diastolic pressure (LVEDP) and ST s...

Effect of losartan on NOX2 transcription following acute myocardial ischemia-reperfusion

Introduction: Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-2 (Nox2) is one of the predominant sources of ROS production during myocardial ischemia-reperfusion and can be induced by angiotensin II. The evidence suggests that pharmacological blockers of renin-angiotensin system can exert direct tissue effects independent of their ability to regulate blood pressure. The mechanism...

Effects of Postconditioning, Preconditioning and Perfusion of L-carnitine During Whole Period of Ischemia/ Reperfusion on Cardiac Hemodynamic Functions and Myocardial Infarction Size in Isolated Rat Heart

The Effect of Verapamil Administred before the Reperfusion Insult in Isolated Preconditioned Rat Heart on the Microsomal ATPase and Mitochondrial Enzyme Activities

Background: Calcium overload and free radical mediated damage in the mitochondria is the most important pathological changes associated with myocardial ischemic-reperfusion injury. The verapamil post-treatment has been previously reported to prevent reperfusion-induced myocardial injury but functional recovery may be delayed due to the drug's inherent direct myocardial depression effect. In the...

Effects of pretreatment with non hypotensive dose of ramiprilat and losartan on myocardial ischemia-reperfusion induced arrhythmias and infarct size in rats

Introduction: Inhibition of renin angiotensin system represents an important approach in the management of cardiovascular diseases. The aim of this study was to explore the effects of pretreatment with non-hypotensive dose of angiotensin converting enzyme (ACE) inhibitor, ramiprilat and angiotensin type 1 (AT1) receptor blocker, losartan on myocardial infarct size and arrhythmias in a rat mo...